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Archexin is a first in class, potent Akt protein kinase inhibitor with potential utility to inhibit cancer cell survival and proliferation, angiogenesis, and drug resistance and is currently being studied in Phase II clinical trials in pancreatic cancer. Rexahn expects to complete these trials by the end of 2010. In previous clinical studies, Archexin has demonstrated an excellent human safety profile, with fatigue being the only noticeable side effect. Archexin has FDA Orphan drug designation for five different cancer types, including renal cell carcinoma, glioblastoma, pancreatic, stomach and ovarian cancers. Initiate clinical program for RX-3117. Rexahn and partner Teva Pharmaceutical Industries are co-developing novel anti-cancer compound, RX-3117, for the treatment of cancer, in particular, gemcitabine-resistant lung cancer.

Furthermore, it is not clear that their estimates include the inevitable cases of progressive vaccinia that would result from inadvertent vaccination or exposure of an immunocompromised person to a vaccine recipient. Second, as the authors acknowledge, age-specific data on the incidence of adverse reactions from an era in which many persons received smallpox vaccine in infancy does not apply to our current population.]