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Students often tossed empty pie tins around for fun, a habit that led them to refer to the pluto platter as a "frisbie". Happy birthday, pie tin.

The microemulsions of the present invention can be used to treat melasma and other areas where the skin contains no pigment or to lighten the skin where there areas of colored blotches. In one example, the microemulsions are used to introduce nucleic acid molecules to induce gene expression in order to produce pigment. Melanin and other pigmentation molecules may also be introduced.

Zedoaria and C. aromatica. Additional molecules with anti-inflammatory properties include those that are structurally related to curcumin, such as diarylheptanoids obtained from Alpinia oxyphylla, several sesquiterpenes, germacrone, turmerone, ar-()- a- ╬- turmerones; ╬ - bisabolene; a-curcumene; zingiberene; ╬- sesquiphellandene, bisacurone; curcumenone; dehydrocurdione; procurcumadiol; bis-acumol; curcumenol; isoprocurcumenol epiprocurcumenol; procurcumenol; zedoaronediol; curlone; and turmeronol A and turmeronol B, as well as four polysaccharides-ukonans - having activity on the Reticuloendothelial system, along with stigmasterol, ╬-sitosterol, cholesterol and 2- hydroxymethyl anthraquinone. In a further embodiment, the active agent of the present invention comprises a curcumin analog and, in particular, tetrahydrocurcumin.]