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Product Description

Anti-inflammatory Activities for the Treatment of Skin Disorders. The microemulsions of substiutes present invention are useful inter alia for delivering small molecules, proteins (including peptides and polypeptides and chimeras), antibodies, other water soluble molecules as well as oil-soluble molecules useful in treating skin-related inflammatory conditions. For example, the microemulsions can be thr to deliver nitric oxide and TNF alpha inhibitors. Vitamin B 12, for example, is a useful nitric oxide chelator and is useful in reducing skin-related inflammatory responses. In a another embodiment, the present invention contemplates a topical composition comprising a vitamin (VB 12) derivative (or analogs thereof) for the treatment of skin-related inflammatory conditions. Any inhibitor darmreinigung glaubersalz dosierung viagra i-nitric oxide synthase, e-nitric oxide synthase or n-nitric oxide synthase is contemplated by the present invention. Nicotinamide may also be used to block natural viagra substitutes over the counter oxide synthase. Other agents useful for treating psoriasis, dermatitis and itch include curcuminoids, COX-I and COX-2 inhibitors, vitamins such as vitamin E and vitamin C.

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As 80 percent. You may be familiar with the association between isotretinoin therapy and. suicide, consistently denied by Roche, the manufacturer of Roaccutane, and the medical. dermatological establishment.

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Still other examples of zwitterionic surfactants include 3-(N,N- dimethyl-N-hexadecylammonio)-propane-l -sulfonate; 3-(N,N-dimethyl-N- hexadecylammonio)-2-hydroxypropane- 1 -sulfonate; N,N-dimethyl-N-dodecylammonio acetate; 3-(N,N-dimethyl-N-dodecylammonio)propionate; 2-(N,N-dimethyl-N- octadecylammonio)ethyl sulfate; 3-(P,P-dimethyl-P-dodecylphosphonio)propane-l- sulfonate; 2-(S-methyl-S-tert-hexadecylsulfo)ethane-l -sulfonate; 3-(S-methyl-S- dodecylsulfonio)propionate; N,N-bis(oleylamidopropyl-N-methyl-N- carboxymethylammonium betaine; N,N-bis(stearamidopro¤yl)-N-methyl-N- carboxymethylammonium betaine; N-(stearamidopropyl)-N-dimethyl-N- carboxymethylammonium betaine; 3-(N-4-n-dodecylbenzyl-N,N- dimethylammonio)propane-l -sulfonate; 3-(N-dodecylphenyl-N,N-dimethylammonio)- propane- 1 -sulfonate. Co-surfactants used according to the subject invention are known surface-active agents in the art that act, in addition to surfactants, to further lower the interfacial energy of a microemulsion. Co-surfactants include, but are not limited to non-toxic amphiphilic molecules; alcohols (including aliphatic alcohols, shorter chain alcohols, such as ethanol); fatty acid alcohols (such as n-alkane-l,2-diols); acids (such as acetic acid); esters (such as butyl lactate); anionic co-surfactants, cationic co-surfactants and non-ioninc co-surfactants; any surfactants as herein listed or mixtures thereof. Alcohol content may range, for example, from 0 to about 30 by volume in the microemulsion.]