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Under the terms of the agreement, Thornton amp; Ross Ltd will conduct the manufacturing scale-up of TPR100 and hold rights to manufacture, market and distribute the product in the UK for the lifetime of the product's patents, which run to at least 2028 in the UK. Futura received an upfront payment and will receive a further milestone payment upon the product receiving UK regulatory marketing authorisation along with royalties on product sales. It is not expected that any further clinical work will be required ahead of a regulatory submission for UK marketing authorisation to be made by Thornton amp; Ross Ltd, which we anticipate in the second half of 2017. We received a written response from the US Food and Drug Administration ("FDA") in December 2016 which confirms our US regulatory strategy for TPR100.

Health care reform, primary care, and the need for research. JAMA. 1993;270:1449-53. Shine K.

Department of Community and Family Medicine. Dartmouth Medical School. Eff Clin Pract.]