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This approach avoids the toxicity common with systemic or oral delivery of, for example, anti-ecchymosis therapies such as extracts of Arnica montana for the treatment of bruising. For example, the microemulsions can be used to deliver nitric oxide and TNF alpha inhibitors to a site of ecchymosis following cosmetic surgery such as rhytidectomy. Vitamin B 12, for example, is a useful nitric oxide chelator and is useful in reducing bruising, also known as ecchymosis. In one embodiment, the present invention contemplates a topical composition comprising a vitamin B 12 derivative (or analogs thereof) for the treatment of bruising.

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We found that pharmacists discovered medication-related problems and consulted with the patients' physicians for a substantial majority of these patients with chronic health conditions. 21 In other analyses, we have reported that pharmaceutical care appears to increase patient awareness about medication side effects.]