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Differentiating-inducing drug Accutane (13-cis-retinoic acid) with other chemotherapy drugs, such as 5-FU. Both Accutane and 5-FU are toxic drugs that must be carefully administered by a. medical oncologist. A combination of 13-cis-retinoic acid (Accutane) and interferon-alpha was. tested in a Phase II trial of 22 patients with pancreatic cancer.

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