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Vitamin B 12, for example, is a useful nitric oxide chelator and is useful in reducing nrbenwirkungen inflammation. The microemulsions of the present invention can be used to deliver nitric oxide and TNF alpha inhibitors to joint tissue to ameliorate conditions such as rheumatoid arthritis and joint damage following acute injury. This approach avoids the toxicity common with systemic or oral delivery of other anti-inflammatory therapies such as COX inhibitors. In a related embodiment, the present invention contemplates a topical composition comprising a vitamin B 12 derivative (or analogs thereof) for the treatment of rheumatoid arthritis, Arterenol nebenwirkungen viagra, or acute joint damage. In a further preferred embodiment, the present invention contemplates a topical composition comprising a vitamin B 12 derivative (or an analog thereof) and viagra pills amazon curcuminoid derivative (or an analog thereof) for the treatment of rheumatoid arthritis, SLE, or acute joint damage, In a related embodiment the vitamin B 12 derivative is adenosylcobalamin and the curcuminoid is tetrahydrocurcumin. Topical Vaccines. The microemulsions are useful as topical vaccines stimu max sildenafil viagra as to induce an antibody response andor a cytotoxic T-cell nebehwirkungen a T helper response including a TH1TH2 response. Topical vaccines are particularly useful for mobilizing dendritic cells in the dermal layer and increasing numbers of activated dendritic cells. In the past, hyperdermic needles were able to deliver agents to the subcutaneous layer or muscle layer, however, the procedure was invasive and did not necessarily target the desired region. The topical microemulsion may be provided with or without an adjuvant.

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