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The Grow America Act, introduced earlier this month in the U. House of Representatives, contains ‚Buy American‚ language that would raise U. content to 100 per cent by 2018 from 60 per cent now. The bill, which must pass both the House and Senate, is part of a resurgence of so-called Buy American rules in numerous recent federal spending bills amid angst about the weak economy. Hundreds, if not thousands, of Canadian jobs could be put at risk if manufacturers are forced to shift production to the U.industry officials warn. Among the companies that would be affected are Bombardier Inc.which makes subway cars, bus maker Nova Bus Corp. of St.

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Additional side effects of NSAIDs include renal insufficiency and failure, gastrointestinal ulceration, bleeding or perforation, exacerbation of hypertension and congestive heart failure. Delivery of therapeutic pharmaceutical agents across the skin addresses the above- mentioned problems by offering a number of potential advantages compared to conventional methods, such as pills and injections, including: (1) little or no degradation or modification of the pharmaceutical agents such as digestion of the proteins by the enzymes and surfactants resident in the stomach and small intestine; (2) an increase in drug effectiveness as the transdermal route avoids first pass metabolism by the liver; (3) minimization of gastrointestinal and other side effects caused by ingestion of the pharmaceutical agent; (4) an improvement in patient comfort and compliance due to a more user-friendly delivery method; and (5) the potential for prolonged and controlled drug delivery. Current research into transdermal transport of water-soluble molecules focuses on: (1) using chemical enhancers to alter the skin's lipid environment; (2) using liposomes to facilitate transdermal transport; (3) using iontophoresis to provide an electrical driving force for transdermal transport; (4) using electroporation to create a new transdermal pathway; and (5) using ultrasound to create a new transdermal pathway.

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